Post by Johan on Nov 4, 2024 23:15:18 GMT -4
Ahmed, M., et al. (2024). A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy. Oncotarget. doi.org/10.18632/oncotarget.28659.
The team documented a 68-year-old male with metastatic ASCP carrying a KRAS G12C mutation. Unexpectedly, after limited success with standard therapies, the patient's cancer responded significantly to pembrolizumab, a type of immune checkpoint inhibitor, despite the absence of typical markers indicating suitability for immunotherapy.
This case suggests that ASCP's unique tumor microenvironment may make it more receptive to immunotherapy. Researchers are hopeful that this new understanding will drive clinical trials focused on immunotherapy specifically for ASCP patients, potentially offering new options for those with limited treatment success.
See the full article in NEWS-MEDICAL:
www.news-medical.net/news/20241104/Unexpected-immunotherapy-success-in-rare-pancreatic-cancer.aspx
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